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KMID : 0369820040340050379
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Jorunal of Korean Pharmaceutical Sciences
2004 Volume.34 No. 5 p.379 ~ p.383
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Statistical Interpretation of Bioequivalence in 2×2 Crossover Design with Missing Observations
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박상규/Park SG
이재영/최성업/윤미경/이재휘/최영욱/Lee JY/Choi SU/Yoon MK/Lee JH/Choi YW
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Abstract
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Statistical interpretations in a bioequivalence trial are considered and studied when the missing observations occurred in 2 × 2 crossover experiment. Patel (1985) suggested the approximate test procedures for carryover effect and drug effect in 2 × 2 crossover design when some of data are missing in the second period. A modified Patel method is newly pro-posed to the bioequivalence trial and it is compared with the current method through the simulation study.
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KEYWORD
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Bioequivalence, Incomplete 2×2 crossover design, Maximum likelihood estimators
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